Graviola ~ Super Fruits

This is actually a small evergreen tree.

Standing upright to about 5–6 m. high with large, glossy, dark green leaves.

It produces yellow-green, heart-shaped, super fruits that are 15–20 cm. in diameter.

It is found in the warmer tropical areas in South and North America, including the Amazon.

The fruit pulp is excellent for making drinks and smoothies.

And though it is slightly sour, it can be eaten out of hand.

Tribal & Herbal Medicine Uses

All parts of the tree can be used in natural medicine.

Including the bark, leaves, roots, fruit, and seeds.

The fruit and fruit juice are taken for worms and parasites.

To cool fevers.

To increase mother's milk after childbirth, and as an astringent for diarrhea and dysentery.

The crushed seeds are used against internal and external parasites.

Such as head lice and worms.

The bark, leaves, and roots are crushed and used in tea.

And are considered sedative, antispasmodic and hypotensive.

Graviola has been used in many different areas to aid in the treatment of many different ailments.

In the Peruvian Andes, the leaves are used in tea for catarrh, inflammation of mucous membranes.

And the seeds are crushed and used to kill parasites.

In the Peruvian Amazon the bark, roots, and leaves are used in tea.

As a sedative and antispasmodic.

And to help with the treatment of diabetes.

In Guyana, the local natives use a leaf and/or bark tea as a sedative and heart tonic.

In the Brazilian Amazon a tincture is used for liver problems.

While the oil of the leaves and any unripe fruit.

Is mixed together with olive oil and used for neuralgia, rheumatism, and arthritis.

In the West Indies, Haiti and Jamaica.

The fruit is used for fevers, parasites and diarrhea.

While the bark or leaf is used as an antispasmodic, sedative, and nervine.

For heart conditions, coughs, flu.

Difficult childbirth, asthma, hypertension, and parasites.

Plant Chemicals

Studies on this super fruit and its health benefits have been conducted since the early 1940s.

Because of the many active compounds and chemicals found in the fruit.

Studies are still being conducted today.

The majority of studies focus on chemicals called Annonaceous acetogenins.

The fruit produces these natural compounds in its leaf, bark, stem and seeds.

Research groups have identified that these chemicals have significant properties.

That work against various types of cancer cells.

Without harming healthy cells.

Four studies were conducted and published in 1998.

Which specify the chemicals and specifically the acetogenins in graviola.

That are demonstrating the strongest anticancerous, antitumorous, and antiviral properties.

Acetogenins are inhibitors of enzyme processes.

Found solely in the membranes of cancerous tumor cells.

This is why they are toxic to cancer cells but are not toxic to healthy cells.

Activities and Clinical Research

In 1976 the National Cancer Institute ran a plant screening program.

And the leaves and stem from the tree showed active toxicity against cancer cells.

Since then, researchers have discovered specific acetogenins in this super fruit.

It's been reported to be selectively toxic in vitro to the following types of tumor cells.

Lung carcinoma cell lines.

Human breast solid tumor lines.

Prostate adenocarcinoma.

Pancreatic carcinoma cell lines.

Colon adenocarcinoma cell lines.

Liver cancer cell lines.

Human lymphoma cell lines.

And multi-drug resistant human breast adenocarcinoma.

In 2003, Taiwan researchers reported that the main graviola acetogenin, Annonacin.

Was highly toxic to ovarian, cervical, breast.

Bladder and skin cancer cell lines at very low dosages.

In March of 2002, Japanese researchers were studying various acetogenins found in several species of plants.

Using mice with lung cancer cells, one third received nothing (the control group).

One third received the chemotherapy drug adriamycin.

And one third received the main graviola acetogenin, Annonacin, at a dosage of 10 mg/kg.

At the end of a two week study.

Five out of six in the control group were still alive and therefore their tumor masses were measured.

The adriamycin group showed a 54.6% reduction of tumor mass over the control group.

However 3 out of the 6 mice had died from toxicity.

The mice receiving Annonacin were all alive and the tumors were inhibited by 57.9%.

This is better than the adriamycin group and there were no toxicity problems.

Current Practical Uses

Cancer research is always on the go.

With several attempts to turn these plant chemicals into healthier versions of chemotherapy.

It has taken nearly 20 years for scientists to successfully chemically reproduce the main chemical, Annonacin.

The next step now is to transform the annonacin and other active acetogenins into patented cancer drugs.

Until these drugs are produced, many cancer patients are not waiting.

But are taking an active role themselves by consuming pure Graviola.

The recommended dosage is said to be 2-3 g. taken 3-4 times daily.


It has cardiodepressant, vasodilator, and hypotensive (lowers blood pressure) actions.

Be aware that large dosages can cause nausea and vomiting.

Avoid combining with ATP-enhancers like CoQ10.

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